THE IMPACT OF GRAFT VERSUS HOST DISEASE ON RELAPSE RATE IN PATIENTS WITH LYMPHOMA DEPENDS ON THE HISTOLOGICAL SUB-TYPE AND THE INTENSITY OF THE CONDITIONING REGIMEN
Identifieur interne : 002779 ( Main/Exploration ); précédent : 002778; suivant : 002780THE IMPACT OF GRAFT VERSUS HOST DISEASE ON RELAPSE RATE IN PATIENTS WITH LYMPHOMA DEPENDS ON THE HISTOLOGICAL SUB-TYPE AND THE INTENSITY OF THE CONDITIONING REGIMEN
Auteurs : Alvaro Urbano-Ispizua [Espagne] ; Steven Z. Pavletic [États-Unis] ; Mary E. Flowers [États-Unis] ; John P. Klein [États-Unis] ; Mei-Jie Zhang [États-Unis] ; Jeanette Carreras [États-Unis] ; Silvia Montoto [Royaume-Uni] ; Miguel-Angel Perales [États-Unis] ; Mahmoud D. Aljurf [Arabie saoudite] ; Görgün Akpek [États-Unis] ; Christopher N. Bredeson [Canada] ; Luciano J. Costa [États-Unis] ; Christopher Dandoy [États-Unis] ; César O. Freytes [États-Unis] ; Henry C. Fung [États-Unis] ; Robert Peter Gale [Royaume-Uni] ; John Gibson [Australie] ; Mehdi Hamadani [États-Unis] ; Robert J. Hayashi [États-Unis] ; Yoshihiro Inamoto [États-Unis] ; David J. Inwards [États-Unis] ; Hillard M. Lazarus [États-Unis] ; David G. Maloney [États-Unis] ; Rodrigo Martino [Espagne] ; Reinhold Munker [États-Unis] ; Taiga Nishihori [États-Unis] ; Richard F. Olsson [Suède] ; David A. Rizzieri [États-Unis] ; Ran Reshef [États-Unis] ; Ayman Saad [Arabie saoudite] ; Bipin N. Savani [États-Unis] ; Harry C. Schouten [Pays-Bas] ; Sonali M. Smith [États-Unis] ; Gérard Socié [France] ; Baldeep Wirk [États-Unis] ; Lolie C. Yu [États-Unis] ; Wael Saber [États-Unis]Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Association thérapeutique, Conditionnement pour greffe (), Estimation de Kaplan-Meier, Femelle, Histocompatibilité, Humains, Immunosuppresseurs (usage thérapeutique), Jeune adulte, Lymphomes (), Lymphomes (anatomopathologie), Lymphomes (mortalité), Lymphomes (physiopathologie), Lymphomes (traitement médicamenteux), Maladie du greffon contre l'hôte (), Modèles de hasards proportionnels, Mâle, Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Rituximab (administration et posologie), Récidive, Résultat thérapeutique, Sujet âgé, Survie sans rechute, Transplantation de cellules souches hématopoïétiques, Études de suivi.
- MESH :
- administration et posologie : Rituximab.
- anatomopathologie : Lymphomes.
- mortalité : Lymphomes.
- physiopathologie : Lymphomes.
- traitement médicamenteux : Lymphomes.
- usage thérapeutique : Immunosuppresseurs, Protocoles de polychimiothérapie antinéoplasique.
- Adolescent, Adulte, Adulte d'âge moyen, Association thérapeutique, Conditionnement pour greffe, Estimation de Kaplan-Meier, Femelle, Histocompatibilité, Humains, Jeune adulte, Lymphomes, Maladie du greffon contre l'hôte, Modèles de hasards proportionnels, Mâle, Récidive, Résultat thérapeutique, Sujet âgé, Survie sans rechute, Transplantation de cellules souches hématopoïétiques, Études de suivi.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Combined Modality Therapy, Disease-Free Survival, Female, Follow-Up Studies, Graft vs Host Disease (complications), Hematopoietic Stem Cell Transplantation, Histocompatibility, Humans, Immunosuppressive Agents (therapeutic use), Kaplan-Meier Estimate, Lymphoma (drug therapy), Lymphoma (mortality), Lymphoma (pathology), Lymphoma (physiopathology), Lymphoma (therapy), Male, Middle Aged, Proportional Hazards Models, Recurrence, Rituximab (administration & dosage), Transplantation Conditioning (methods), Treatment Outcome, Young Adult.
- MESH :
- chemical , administration & dosage : Rituximab.
- chemical , therapeutic use : Immunosuppressive Agents.
- complications : Graft vs Host Disease.
- drug therapy : Lymphoma.
- methods : Transplantation Conditioning.
- mortality : Lymphoma.
- pathology : Lymphoma.
- physiopathology : Lymphoma.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- therapy : Lymphoma.
- Adolescent, Adult, Aged, Combined Modality Therapy, Disease-Free Survival, Female, Follow-Up Studies, Hematopoietic Stem Cell Transplantation, Histocompatibility, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Proportional Hazards Models, Recurrence, Treatment Outcome, Young Adult.
Abstract
To analyze the impact of graft versus host disease (GVHD) on the relapse rate of different lymphoma subtypes after allogeneic hematopoietic cell transplantation (allo-HCT).
Adult patients with a diagnosis of Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), peripheral T-cell lymphoma (PTCL), or mantle cell lymphoma (MCL) undergoing HLA-identical sibling or unrelated donor HCT between 1997 and 2009 were included.
Two thousand six hundred and eleven cases were included. Reduced-intensity conditioning (RIC) regimen was used in 62.8% of the transplants. In a multivariate analysis of myeloablative cases (n=970), neither acute (aGVHD) nor chronic GVHD (cGVHD) were significantly associated with a lower incidence of relapse/progression in any lymphoma subtype. In contrast, the analysis of RIC cases (n=1641) showed that cGVHD was associated with a lower incidence of relapse/progression in FL (RR 0.51, p=0.049) and in MCL (RR 0.41, p=0.019). Patients with FL or MCL developing both aGVHD and cGVHD had the lowest risk of relapse (RR 0.14, p=0.007; and RR 0.15, p=0.0019, respectively). Of interest, the effect of GVHD on decreasing relapse was similar in patients with sensitive disease and chemoresistant disease. Unfortunately, both aGVHD and cGVHD had a deleterious effect on treatment related mortality (TRM) and overall survival (OS) in FL cases, and did not impact TRM, OS or PFS in MCL.
This study reinforces the use of RIC allo-HCT as a platform for immunotherapy in follicular and mantle cell lymphoma patients.
Url:
DOI: 10.1016/j.bbmt.2015.05.010
PubMed: 25981509
PubMed Central: 4568162
Affiliations:
- Arabie saoudite, Australie, Canada, Espagne, France, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Alabama, Angleterre, Arizona, Caroline du Nord, Catalogne, East Middle Sweden, Floride, Grand Londres, Illinois, Louisiane, Maryland, Minnesota, Missouri (État), Ohio, Pennsylvanie, Svealand, Tennessee, Texas, Washington (État), Wisconsin, État de New York, Île-de-France
- Barcelone, Londres, Paris, Stockholm, Uppsala
- Université d'Uppsala
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Le document en format XML
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Aljurf</name><affiliation wicri:level="1"><nlm:aff id="A8"> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgün" last="Akpek">Görgün Akpek</name><affiliation wicri:level="2"><nlm:aff id="A9">Section of Hematology Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Section of Hematology Oncology, Banner MD Anderson Cancer Center, Gilbert</wicri:cityArea></affiliation></author><author><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name><affiliation wicri:level="1"><nlm:aff id="A10">The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name><affiliation wicri:level="2"><nlm:aff id="A11">Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Dandoy, Christopher" sort="Dandoy, Christopher" uniqKey="Dandoy C" first="Christopher" last="Dandoy">Christopher Dandoy</name><affiliation wicri:level="2"><nlm:aff id="A12">Cincinnati Children's Hospital Medical Center, Cincinnati, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cincinnati Children's Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="César O." last="Freytes">César O. Freytes</name><affiliation wicri:level="2"><nlm:aff id="A13">South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio</wicri:cityArea></affiliation></author><author><name sortKey="Fung, Henry C" sort="Fung, Henry C" uniqKey="Fung H" first="Henry C." last="Fung">Henry C. Fung</name><affiliation wicri:level="2"><nlm:aff id="A14"> Department of Medical Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea> Department of Medical Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation wicri:level="3"><nlm:aff id="A15">Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gibson, John" sort="Gibson, John" uniqKey="Gibson J" first="John" last="Gibson">John Gibson</name><affiliation wicri:level="1"><nlm:aff id="A16">Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Institute of Haematology, Royal Prince Alfred Hospital, Camperdown</wicri:regionArea><wicri:noRegion>Camperdown</wicri:noRegion></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation wicri:level="2"><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Hayashi, Robert J" sort="Hayashi, Robert J" uniqKey="Hayashi R" first="Robert J." last="Hayashi">Robert J. Hayashi</name><affiliation wicri:level="2"><nlm:aff id="A17">Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation wicri:level="2"><nlm:aff id="A3">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Inwards, David J" sort="Inwards, David J" uniqKey="Inwards D" first="David J." last="Inwards">David J. Inwards</name><affiliation wicri:level="2"><nlm:aff id="A18">Division of Hematology, Mayo Clinic, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Hematology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name><affiliation wicri:level="2"><nlm:aff id="A19">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Maloney, David G" sort="Maloney, David G" uniqKey="Maloney D" first="David G." last="Maloney">David G. Maloney</name><affiliation wicri:level="2"><nlm:aff id="A3">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name><affiliation wicri:level="3"><nlm:aff id="A20">Divison of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Divison of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Munker, Reinhold" sort="Munker, Reinhold" uniqKey="Munker R" first="Reinhold" last="Munker">Reinhold Munker</name><affiliation wicri:level="2"><nlm:aff id="A21">Divison of Hematology/Oncology, Department of Internal Medicine, Louisiana State University Health Shreveport, LA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Louisiane</region></placeName><wicri:cityArea>Divison of Hematology/Oncology, Department of Internal Medicine, Louisiana State University Health Shreveport</wicri:cityArea></affiliation></author><author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name><affiliation wicri:level="2"><nlm:aff id="A22"> Department of Medical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea> Department of Medical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F." last="Olsson">Richard F. Olsson</name><affiliation wicri:level="3"><nlm:aff id="A23">Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A24">Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Centre for Clinical Research Sörmland, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Rizzieri, David A" sort="Rizzieri, David A" uniqKey="Rizzieri D" first="David A." last="Rizzieri">David A. Rizzieri</name><affiliation wicri:level="2"><nlm:aff id="A25">Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Reshef, Ran" sort="Reshef, Ran" uniqKey="Reshef R" first="Ran" last="Reshef">Ran Reshef</name><affiliation wicri:level="2"><nlm:aff id="A26">Department of Medicine, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Saad, Ayman" sort="Saad, Ayman" uniqKey="Saad A" first="Ayman" last="Saad">Ayman Saad</name><affiliation wicri:level="1"><nlm:aff id="A8"> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation wicri:level="2"><nlm:aff id="A27">Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Hematology, Academische Ziekenhuis, Maastricht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, Academische Ziekenhuis, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Sonali M" sort="Smith, Sonali M" uniqKey="Smith S" first="Sonali M." last="Smith">Sonali M. Smith</name><affiliation wicri:level="2"><nlm:aff id="A29">Section of Hematology/Oncology, The University of Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Section of Hematology/Oncology, The University of Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name><affiliation wicri:level="3"><nlm:aff id="A30">Department of Hematology, Hôpital Saint Louis, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Hematology, Hôpital Saint Louis, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation wicri:level="2"><nlm:aff id="A31">Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook</wicri:cityArea></affiliation></author><author><name sortKey="Yu, Lolie C" sort="Yu, Lolie C" uniqKey="Yu L" first="Lolie C." last="Yu">Lolie C. Yu</name><affiliation wicri:level="2"><nlm:aff id="A32">Division of Hematology/Oncology, Center for Cancer and Blood Disorders, Children's Hospital/Louisiana State University Medical Center, New Orleans, LA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Louisiane</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Center for Cancer and Blood Disorders, Children's Hospital/Louisiana State University Medical Center, New Orleans</wicri:cityArea></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation wicri:level="2"><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25981509</idno><idno type="pmc">4568162</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568162</idno><idno type="RBID">PMC:4568162</idno><idno type="doi">10.1016/j.bbmt.2015.05.010</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002191</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002191</idno><idno type="wicri:Area/Pmc/Curation">002042</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002042</idno><idno type="wicri:Area/Pmc/Checkpoint">000C95</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C95</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002915</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002915</idno><idno type="wicri:Area/PubMed/Curation">002846</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002846</idno><idno type="wicri:Area/PubMed/Checkpoint">002846</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002846</idno><idno type="wicri:Area/Ncbi/Merge">002577</idno><idno type="wicri:Area/Ncbi/Curation">002577</idno><idno type="wicri:Area/Ncbi/Checkpoint">002577</idno><idno type="wicri:doubleKey">1083-8791:2015:Urbano Ispizua A:the:impact:of</idno><idno type="wicri:Area/Main/Merge">002779</idno><idno type="wicri:Area/Main/Curation">002779</idno><idno type="wicri:Area/Main/Exploration">002779</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">THE IMPACT OF GRAFT VERSUS HOST DISEASE ON RELAPSE RATE IN PATIENTS WITH LYMPHOMA DEPENDS ON THE HISTOLOGICAL SUB-TYPE AND THE INTENSITY OF THE CONDITIONING REGIMEN</title><author><name sortKey="Urbano Ispizua, Alvaro" sort="Urbano Ispizua, Alvaro" uniqKey="Urbano Ispizua A" first="Alvaro" last="Urbano-Ispizua">Alvaro Urbano-Ispizua</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Hematology, Hospital Clinic, University of Barcelona, IDIBAPS, and Institute of Research Josep Carreras, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Hematology, Hospital Clinic, University of Barcelona, IDIBAPS, and Institute of Research Josep Carreras, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pavletic, Steven Z" sort="Pavletic, Steven Z" uniqKey="Pavletic S" first="Steven Z." last="Pavletic">Steven Z. Pavletic</name><affiliation wicri:level="2"><nlm:aff id="A2">Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Flowers, Mary E" sort="Flowers, Mary E" uniqKey="Flowers M" first="Mary E." last="Flowers">Mary E. Flowers</name><affiliation wicri:level="2"><nlm:aff id="A3">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P." last="Klein">John P. Klein</name><affiliation wicri:level="2"><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Zhang, Mei Jie" sort="Zhang, Mei Jie" uniqKey="Zhang M" first="Mei-Jie" last="Zhang">Mei-Jie Zhang</name><affiliation wicri:level="2"><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Carreras, Jeanette" sort="Carreras, Jeanette" uniqKey="Carreras J" first="Jeanette" last="Carreras">Jeanette Carreras</name><affiliation wicri:level="2"><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Montoto, Silvia" sort="Montoto, Silvia" uniqKey="Montoto S" first="Silvia" last="Montoto">Silvia Montoto</name><affiliation wicri:level="3"><nlm:aff id="A6">Department of Haemato-oncology, St. Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haemato-oncology, St. Bartholomew's Hospital, Barts Health NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Perales, Miguel Angel" sort="Perales, Miguel Angel" uniqKey="Perales M" first="Miguel-Angel" last="Perales">Miguel-Angel Perales</name><affiliation wicri:level="2"><nlm:aff id="A7">Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation wicri:level="1"><nlm:aff id="A8"> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgün" last="Akpek">Görgün Akpek</name><affiliation wicri:level="2"><nlm:aff id="A9">Section of Hematology Oncology, Banner MD Anderson Cancer Center, Gilbert, AZ</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Section of Hematology Oncology, Banner MD Anderson Cancer Center, Gilbert</wicri:cityArea></affiliation></author><author><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name><affiliation wicri:level="1"><nlm:aff id="A10">The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Ottawa Hospital Blood and Marrow Transplant Program and the Ottawa Hospital Research Institute, Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name><affiliation wicri:level="2"><nlm:aff id="A11">Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Dandoy, Christopher" sort="Dandoy, Christopher" uniqKey="Dandoy C" first="Christopher" last="Dandoy">Christopher Dandoy</name><affiliation wicri:level="2"><nlm:aff id="A12">Cincinnati Children's Hospital Medical Center, Cincinnati, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cincinnati Children's Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="César O." last="Freytes">César O. Freytes</name><affiliation wicri:level="2"><nlm:aff id="A13">South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio</wicri:cityArea></affiliation></author><author><name sortKey="Fung, Henry C" sort="Fung, Henry C" uniqKey="Fung H" first="Henry C." last="Fung">Henry C. Fung</name><affiliation wicri:level="2"><nlm:aff id="A14"> Department of Medical Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea> Department of Medical Oncology, Fox Chase Cancer Center, Temple Health, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name><affiliation wicri:level="3"><nlm:aff id="A15">Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gibson, John" sort="Gibson, John" uniqKey="Gibson J" first="John" last="Gibson">John Gibson</name><affiliation wicri:level="1"><nlm:aff id="A16">Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Institute of Haematology, Royal Prince Alfred Hospital, Camperdown</wicri:regionArea><wicri:noRegion>Camperdown</wicri:noRegion></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation wicri:level="2"><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Hayashi, Robert J" sort="Hayashi, Robert J" uniqKey="Hayashi R" first="Robert J." last="Hayashi">Robert J. Hayashi</name><affiliation wicri:level="2"><nlm:aff id="A17">Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Division of Pediatric Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation wicri:level="2"><nlm:aff id="A3">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Inwards, David J" sort="Inwards, David J" uniqKey="Inwards D" first="David J." last="Inwards">David J. Inwards</name><affiliation wicri:level="2"><nlm:aff id="A18">Division of Hematology, Mayo Clinic, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Hematology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name><affiliation wicri:level="2"><nlm:aff id="A19">Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Maloney, David G" sort="Maloney, David G" uniqKey="Maloney D" first="David G." last="Maloney">David G. Maloney</name><affiliation wicri:level="2"><nlm:aff id="A3">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name><affiliation wicri:level="3"><nlm:aff id="A20">Divison of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Divison of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Munker, Reinhold" sort="Munker, Reinhold" uniqKey="Munker R" first="Reinhold" last="Munker">Reinhold Munker</name><affiliation wicri:level="2"><nlm:aff id="A21">Divison of Hematology/Oncology, Department of Internal Medicine, Louisiana State University Health Shreveport, LA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Louisiane</region></placeName><wicri:cityArea>Divison of Hematology/Oncology, Department of Internal Medicine, Louisiana State University Health Shreveport</wicri:cityArea></affiliation></author><author><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name><affiliation wicri:level="2"><nlm:aff id="A22"> Department of Medical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea> Department of Medical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F." last="Olsson">Richard F. Olsson</name><affiliation wicri:level="3"><nlm:aff id="A23">Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A24">Centre for Clinical Research Sörmland, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Centre for Clinical Research Sörmland, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Rizzieri, David A" sort="Rizzieri, David A" uniqKey="Rizzieri D" first="David A." last="Rizzieri">David A. Rizzieri</name><affiliation wicri:level="2"><nlm:aff id="A25">Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Reshef, Ran" sort="Reshef, Ran" uniqKey="Reshef R" first="Ran" last="Reshef">Ran Reshef</name><affiliation wicri:level="2"><nlm:aff id="A26">Department of Medicine, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Saad, Ayman" sort="Saad, Ayman" uniqKey="Saad A" first="Ayman" last="Saad">Ayman Saad</name><affiliation wicri:level="1"><nlm:aff id="A8"> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea> Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation wicri:level="2"><nlm:aff id="A27">Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation wicri:level="1"><nlm:aff id="A28">Department of Hematology, Academische Ziekenhuis, Maastricht, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hematology, Academische Ziekenhuis, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Sonali M" sort="Smith, Sonali M" uniqKey="Smith S" first="Sonali M." last="Smith">Sonali M. Smith</name><affiliation wicri:level="2"><nlm:aff id="A29">Section of Hematology/Oncology, The University of Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Section of Hematology/Oncology, The University of Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name><affiliation wicri:level="3"><nlm:aff id="A30">Department of Hematology, Hôpital Saint Louis, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Hematology, Hôpital Saint Louis, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation wicri:level="2"><nlm:aff id="A31">Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Internal Medicine, Stony Brook University Medical Center, Stony Brook</wicri:cityArea></affiliation></author><author><name sortKey="Yu, Lolie C" sort="Yu, Lolie C" uniqKey="Yu L" first="Lolie C." last="Yu">Lolie C. Yu</name><affiliation wicri:level="2"><nlm:aff id="A32">Division of Hematology/Oncology, Center for Cancer and Blood Disorders, Children's Hospital/Louisiana State University Medical Center, New Orleans, LA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Louisiane</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Center for Cancer and Blood Disorders, Children's Hospital/Louisiana State University Medical Center, New Orleans</wicri:cityArea></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation wicri:level="2"><nlm:aff id="A4">Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="ISSN">1083-8791</idno><idno type="eISSN">1523-6536</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Combined Modality Therapy</term><term>Disease-Free Survival</term><term>Female</term><term>Follow-Up Studies</term><term>Graft vs Host Disease (complications)</term><term>Hematopoietic Stem Cell Transplantation</term><term>Histocompatibility</term><term>Humans</term><term>Immunosuppressive Agents (therapeutic use)</term><term>Kaplan-Meier Estimate</term><term>Lymphoma (drug therapy)</term><term>Lymphoma (mortality)</term><term>Lymphoma (pathology)</term><term>Lymphoma (physiopathology)</term><term>Lymphoma (therapy)</term><term>Male</term><term>Middle Aged</term><term>Proportional Hazards Models</term><term>Recurrence</term><term>Rituximab (administration & dosage)</term><term>Transplantation Conditioning (methods)</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique</term><term>Conditionnement pour greffe ()</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Histocompatibilité</term><term>Humains</term><term>Immunosuppresseurs (usage thérapeutique)</term><term>Jeune adulte</term><term>Lymphomes ()</term><term>Lymphomes (anatomopathologie)</term><term>Lymphomes (mortalité)</term><term>Lymphomes (physiopathologie)</term><term>Lymphomes (traitement médicamenteux)</term><term>Maladie du greffon contre l'hôte ()</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Rituximab (administration et posologie)</term><term>Récidive</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Survie sans rechute</term><term>Transplantation de cellules souches hématopoïétiques</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Rituximab</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Rituximab</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphomes</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Graft vs Host Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphoma</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Transplantation Conditioning</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Lymphoma</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Lymphomes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphoma</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphomes</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphoma</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lymphoma</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphomes</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Immunosuppresseurs</term><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Combined Modality Therapy</term><term>Disease-Free Survival</term><term>Female</term><term>Follow-Up Studies</term><term>Hematopoietic Stem Cell Transplantation</term><term>Histocompatibility</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Male</term><term>Middle Aged</term><term>Proportional Hazards Models</term><term>Recurrence</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique</term><term>Conditionnement pour greffe</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Histocompatibilité</term><term>Humains</term><term>Jeune adulte</term><term>Lymphomes</term><term>Maladie du greffon contre l'hôte</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Récidive</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Survie sans rechute</term><term>Transplantation de cellules souches hématopoïétiques</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">To analyze the impact of graft versus host disease (GVHD) on the relapse rate of different lymphoma subtypes after allogeneic hematopoietic cell transplantation (allo-HCT).</p></sec><sec id="S2"><title>Patients and Methods</title><p id="P2">Adult patients with a diagnosis of Hodgkin lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), peripheral T-cell lymphoma (PTCL), or mantle cell lymphoma (MCL) undergoing HLA-identical sibling or unrelated donor HCT between 1997 and 2009 were included.</p></sec><sec id="S3"><title>Results</title><p id="P3">Two thousand six hundred and eleven cases were included. Reduced-intensity conditioning (RIC) regimen was used in 62.8% of the transplants. In a multivariate analysis of myeloablative cases (n=970), neither acute (aGVHD) nor chronic GVHD (cGVHD) were significantly associated with a lower incidence of relapse/progression in any lymphoma subtype. In contrast, the analysis of RIC cases (n=1641) showed that cGVHD was associated with a lower incidence of relapse/progression in FL (RR 0.51, p=0.049) and in MCL (RR 0.41, p=0.019). Patients with FL or MCL developing both aGVHD and cGVHD had the lowest risk of relapse (RR 0.14, p=0.007; and RR 0.15, p=0.0019, respectively). Of interest, the effect of GVHD on decreasing relapse was similar in patients with sensitive disease and chemoresistant disease. Unfortunately, both aGVHD and cGVHD had a deleterious effect on treatment related mortality (TRM) and overall survival (OS) in FL cases, and did not impact TRM, OS or PFS in MCL.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">This study reinforces the use of RIC allo-HCT as a platform for immunotherapy in follicular and mantle cell lymphoma patients.</p></sec></div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Alabama</li><li>Angleterre</li><li>Arizona</li><li>Caroline du Nord</li><li>Catalogne</li><li>East Middle Sweden</li><li>Floride</li><li>Grand Londres</li><li>Illinois</li><li>Louisiane</li><li>Maryland</li><li>Minnesota</li><li>Missouri (État)</li><li>Ohio</li><li>Pennsylvanie</li><li>Svealand</li><li>Tennessee</li><li>Texas</li><li>Washington (État)</li><li>Wisconsin</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Barcelone</li><li>Londres</li><li>Paris</li><li>Stockholm</li><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Urbano Ispizua, Alvaro" sort="Urbano Ispizua, Alvaro" uniqKey="Urbano Ispizua A" first="Alvaro" last="Urbano-Ispizua">Alvaro Urbano-Ispizua</name></region><name sortKey="Martino, Rodrigo" sort="Martino, Rodrigo" uniqKey="Martino R" first="Rodrigo" last="Martino">Rodrigo Martino</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Pavletic, Steven Z" sort="Pavletic, Steven Z" uniqKey="Pavletic S" first="Steven Z." last="Pavletic">Steven Z. Pavletic</name></region><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Görgün" last="Akpek">Görgün Akpek</name><name sortKey="Carreras, Jeanette" sort="Carreras, Jeanette" uniqKey="Carreras J" first="Jeanette" last="Carreras">Jeanette Carreras</name><name sortKey="Costa, Luciano J" sort="Costa, Luciano J" uniqKey="Costa L" first="Luciano J." last="Costa">Luciano J. Costa</name><name sortKey="Dandoy, Christopher" sort="Dandoy, Christopher" uniqKey="Dandoy C" first="Christopher" last="Dandoy">Christopher Dandoy</name><name sortKey="Flowers, Mary E" sort="Flowers, Mary E" uniqKey="Flowers M" first="Mary E." last="Flowers">Mary E. Flowers</name><name sortKey="Freytes, Cesar O" sort="Freytes, Cesar O" uniqKey="Freytes C" first="César O." last="Freytes">César O. Freytes</name><name sortKey="Fung, Henry C" sort="Fung, Henry C" uniqKey="Fung H" first="Henry C." last="Fung">Henry C. Fung</name><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><name sortKey="Hayashi, Robert J" sort="Hayashi, Robert J" uniqKey="Hayashi R" first="Robert J." last="Hayashi">Robert J. Hayashi</name><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><name sortKey="Inwards, David J" sort="Inwards, David J" uniqKey="Inwards D" first="David J." last="Inwards">David J. Inwards</name><name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P." last="Klein">John P. Klein</name><name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P." last="Klein">John P. Klein</name><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name><name sortKey="Maloney, David G" sort="Maloney, David G" uniqKey="Maloney D" first="David G." last="Maloney">David G. Maloney</name><name sortKey="Munker, Reinhold" sort="Munker, Reinhold" uniqKey="Munker R" first="Reinhold" last="Munker">Reinhold Munker</name><name sortKey="Nishihori, Taiga" sort="Nishihori, Taiga" uniqKey="Nishihori T" first="Taiga" last="Nishihori">Taiga Nishihori</name><name sortKey="Perales, Miguel Angel" sort="Perales, Miguel Angel" uniqKey="Perales M" first="Miguel-Angel" last="Perales">Miguel-Angel Perales</name><name sortKey="Reshef, Ran" sort="Reshef, Ran" uniqKey="Reshef R" first="Ran" last="Reshef">Ran Reshef</name><name sortKey="Rizzieri, David A" sort="Rizzieri, David A" uniqKey="Rizzieri D" first="David A." last="Rizzieri">David A. Rizzieri</name><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><name sortKey="Smith, Sonali M" sort="Smith, Sonali M" uniqKey="Smith S" first="Sonali M." last="Smith">Sonali M. Smith</name><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><name sortKey="Yu, Lolie C" sort="Yu, Lolie C" uniqKey="Yu L" first="Lolie C." last="Yu">Lolie C. Yu</name><name sortKey="Zhang, Mei Jie" sort="Zhang, Mei Jie" uniqKey="Zhang M" first="Mei-Jie" last="Zhang">Mei-Jie Zhang</name><name sortKey="Zhang, Mei Jie" sort="Zhang, Mei Jie" uniqKey="Zhang M" first="Mei-Jie" last="Zhang">Mei-Jie Zhang</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Montoto, Silvia" sort="Montoto, Silvia" uniqKey="Montoto S" first="Silvia" last="Montoto">Silvia Montoto</name></region><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name></noRegion><name sortKey="Saad, Ayman" sort="Saad, Ayman" uniqKey="Saad A" first="Ayman" last="Saad">Ayman Saad</name></country><country name="Canada"><noRegion><name sortKey="Bredeson, Christopher N" sort="Bredeson, Christopher N" uniqKey="Bredeson C" first="Christopher N." last="Bredeson">Christopher N. Bredeson</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Gibson, John" sort="Gibson, John" uniqKey="Gibson J" first="John" last="Gibson">John Gibson</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F." last="Olsson">Richard F. Olsson</name></region><name sortKey="Olsson, Richard F" sort="Olsson, Richard F" uniqKey="Olsson R" first="Richard F." last="Olsson">Richard F. Olsson</name></country><country name="Pays-Bas"><noRegion><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gérard" last="Socié">Gérard Socié</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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